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KMID : 1146920210510020223
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Journal of Pharmaceutical Investigation
2021 Volume.51 No. 2 p.223 ~ p.232
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Anti-inflammatory effects of a topical emulsion containing Helianthus annuus oil, glycerin, and vitamin B3 in mice
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Freitas Leandro Mendes
Antunes Flavia Tasmin Techera
Obach Eliane Sempe
Correa Aurea Pandolfo
Wiiland Elenir
de Mello Feliciano Liciane
Reinicke Adriana
Amado Gabriela Jouglard Vasquez
Grivicich Ivana
Fialho Maria Fernanda Pessano
Rebelo Isadora Nunes
de Souza Alessandra Hubner
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Abstract
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Purpose: The pharmaceutical industry has been searching for drugs that aim at the prevention, the protection, and the recovery of the skin. Thus, the aim of this study was to evaluate the anti-inflammatory and anti-edematogenic activities of a topical emulsion containing Helianthus annuus oil (5%), glycerin (30%), and vitamin B3 (5%).
Methods: The aim was verified through chronic inflammatory responses and edema that were induced by irritant croton oil in the ears of mice, followed by histological and leukocyte infiltration. The study also affirmed the stability and the cytotoxicity of the emulsion.
Results: A stable, homogeneous, shiny, slightly-white, and gelatinous emulsion was obtained. The cytotoxicity evaluation allowed for the verification that only in high concentrations were unsatisfactory results presented. The treatment was effective in reversing the inflammatory parameters that were induced by croton oil, such as edema, neutrophil migration, and cell hyperproliferation.
Conclusion: The developed emulsion containing sunflower oil, glycerin, and vitamin B3 had parameters of stability and presented anti-inflammatory activities. The researchers’ findings suggest that the topical use of this formulation is a new and novel strategy for the treatment of inflammatory conditions of the skin.
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KEYWORD
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Anti-inflammatory, Glycerin, Vitamin B3, Emulsion, Sunflower oil, Ear edema
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